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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

TLR inhibits CYLD. 1 / 1

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"TLR signaling normally prevents caspase-8-, FADD- and RIPK3 dependent cell death pathways both through transcriptional upregulation of pro survival genes and through post-translational modification of key signaling proteins such as RIPK1 [XREF_BIBR], as well as inducing caspase-8-dependent cleavage of the pro necroptotic molecule CYLD [XREF_BIBR]."

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Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...