IndraLab

Statements

CYLD activates STAT1. 5 / 5
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"This indirect regulation of STAT1 signaling by CYLD resembles the function of the deubiquitinating enzyme A20, which also inhibits STAT1 activation indirectly by suppressing NF-kappaB activation."
26834734
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"In accordance with the CYLD independent activation of STAT1 by IFN-gamma, we could not detect a direct interaction of CYLD with STAT1."
26834734
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"Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control."
39958342
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"Moreover, treatment of normal macrophages with CYLD siRNA enhanced activation of STAT-1, leading to increases in expressions of maturation markers and IL-6 production as well as suppression in cell apoptosis and phagocytosis, while macrophage phagocytosis from AML M4/M5b was higher than that from healthy controls upon CYLD siRNA transfection through STAT1 signalling."
37549179
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"To confirm the inhibition of STAT1 activation by SPATA2 and CYLD, we generated STAT1 reporter cells via lentiviral transduction of STAT1-responsive transcriptional elements (SRE) driving luciferase expression."
36531014