IndraLab

Statements

CCL5 activates GPR75. 4 / 5
| 1 3
reach
"Recent studies reported that pancreatic islets as well as beta cell lines express GPR75 and that CCL5 stimulates insulin secretion via PLC-activated Ca influx in a GPR75-dependent manner; however, they also did not document direct binding or interaction between GPR75 and CCL5 (Gencoglu et al., 2019; Liu et al., 2013)."
33974269
reach
"2 Moreover, administration of CCL5 did not activate GPR75 signaling in endothelial cells, and the size of GPR75 protein isolated was smaller than expected."
28546348
reach
"Moreover, CCL5 promotes a time dependent internalization of GPR75."
29772059
eidos
"Activation of GPR75 by CCL5 was reported to attenuate the neurotoxic effect of amyloid-beta , which is a hallmark of Alzheimer 's disease ( 36 ) ."
33013649