IndraLab

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CCL5 activates GPR75. 9 / 10
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"The effects of chemerin on glucagon and somatostatin secretion are unknown.Human islets express mRNAs coding for numerous distinct chemokine receptors: seven belong to the C–C motif receptor family (C[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"There are a few studies suggesting that the chemokine CCL5 activates GPR75 via a G α protein-coupled PLC-mediated signal transduction pathway in cells overexpressing GPR75, pancreatic islets and neuroblastoma cell lines (2–4)."
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"2 Moreover, administration of CCL5 did not activate GPR75 signaling in endothelial cells, and the size of GPR75 protein isolated was smaller than expected."
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"Moreover, CCL5 promotes a time dependent internalization of GPR75."
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"Activation of GPR75 by CCL5 was reported to attenuate the neurotoxic effect of amyloid-beta , which is a hallmark of Alzheimer 's disease ( 36 ) ."
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"Therefore, the beneficial effects of CCL5 on the nervous system may be mediated by CCL5-induced negative regulation rather than GPR75 activation."
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"Only recently, GPR75 has been shown to be activated by at least two ligands, the chemokine CCL5 (Dedoni et al. 2018, Ignatov et al. 2006) and the eicosanoid 20-Hydroxyeicosatetraenoic acid (20-HETE) (Garcia et al. 2017, Fan & Roman 2017)."
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"Recent studies reported that pancreatic islets as well as beta cell lines express GPR75 and that CCL5 stimulates insulin secretion via PLC-activated Ca influx in a GPR75-dependent manner; however, they also did not document direct binding or interaction between GPR75 and CCL5 (Gencoglu et al., 2019; Liu et al., 2013)."
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"One interesting candidate that was identified by this GPCRome screening is the Gq-coupled receptor GPR75, which is activated by CCL5 (chemokine (C C motif) ligand 5)."
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