IndraLab

Statements

Staurosporine inhibits IKBKB. 11 / 11
8 | 3
tas
No evidence text available
25662701
tas
No evidence text available
23994329
reach
"The strong inhibition of IKKbeta by staurosporine (K (i) = 172 nM) and ADP (K (i) = 136 nM) provides a rationale and structural framework for designing potent ATP-site inhibitors of IKKbeta, which is an attractive drug target for inflammatory diseases."
10551820
tas
No evidence text available
19481464
tas
No evidence text available
reach
"IKK-1 +2 and IKK-2 had similar K (m) values for ATP and GST-biotin-IkappaB (1-54) and were similarly inhibited by staurosporine and two of its analogues K252a and K252b, suggesting that most of the IkappaBalpha kinase activity in the IKK-1 +2 complex may be attributed to IKK-2."
10527519
tas
No evidence text available
24389511
tas
No evidence text available
15225717
tas
No evidence text available
22037378
tas
No evidence text available
19338355
reach
"Staurosporine can inhibit IKK2 by these regions through the binding of targets and as a reference to other compounds."
24987428