IndraLab

Statements


| 4

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"In the current study, we show that arsenite down-regulates Akt and c-Fos by ubiquitination, decreases AP-1 activity and causes cell cycle dysregulation and apoptotic cell death."

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"Co-exposure of the cells with both arsenite and MG-132 restored the arsenite induced c-Fos degradation (XREF_FIG)."

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"The possibility that arsenite treatment prevented the participation of Fra1 or c-Fos in large complexes was examined."

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"In summary, our present study reveals that under conditions of reduced GSH availability, arsenite down-regulated Akt and c-Fos via the ubiquitin-prteasome-mediated degradation."