IndraLab

Statements

USP1 activates ID1. 20 / 20
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"A link between USP1 and Id1 has been reported in AML, where USP1 inhibition using multiple small molecule inhibitors promoted the degradation of Id1 in a dose-dependent manner [ 74 ]."
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"More importantly , inhibition of USP1 leads to the downregulated expression of ID1 , further causing the inactivation of PI3K / AKT pathway ."
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"These data suggest that ATAD5 regulates interactions between UAF1 and ID1 and this regulatory mechanism for ID1 is different from USP1 mediated ID1 regulation."
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"Besides DNA repair proteins, USP1 also promotes stabilization of ID (ID1-ID4) proteins 31."
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"The small molecule inhibitor of USP1 promotes ID1 degradation and has cytotoxicity to leukemic cells [XREF_BIBR]."
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"In contrast to USP1 knockdown, USP1 overexpression in primary human mesenchymal stem cells (hMSCs) caused ID protein accumulation and interfered with normal differentiation."
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"Collectively, these results indicate that the novel small molecule inhibitors of USP1 promote ID1 degradation and are cytotoxic to leukemic cells."
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"USP1 knockdown specificity was confirmed with shRNA resistant USP1, which restored ID1, ID2, and ID3 to basal levels."
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"USP1 knockdown has been observed to downregulate the DNA repair-related substrates FANCD2 and ID1; thus, it can be considered a target for regulating DNA repair[24]."
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"The APC/C–CDH1 complex targets these Id proteins for degradation to promote cell cycle arrest, whereas the ubiquitin-specific protease 1 (USP1) modulates Id protein abundance to control cell growth (Williams et al. 2011)."
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"USP1 enhanced protein stability of the ID1 and CHEK1, important regulators of DNA damage response and stem cell maintenance (Lee et al., 2016)."
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"USP1 removes the polyubiquitin chains and rescues ID1 from degradation."
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"A Previous study reported that overexpression of ubiquitin-specific protease 1 ( USP1 ) increases ID1 expression , leading to centrosome duplication [ 17 ] ."
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"Moreover, the knockdown of USP1 can induce B-cell ALL apoptosis through inhibiting ID1/AKT signaling pathway [222] ."
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"A doxycycline induced USP1 shRNA suppressed USP1 expression and reduced ID1 and ID2 in the xenografts."
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"USP1 promotes ID protein stability."
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"Here, we demonstrate that targeting USP1 with a small molecule, can promote ID1 degradation and cell death in multiple leukemic cell lines."
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"USP1, highly expressed in GBM and particularly in cells positive for GSC-enrichment markers (CD133 or CD15), modulates the stability of ID1 and CHEK1, which are critical for DDR and stem cell maintenance."
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"Another USP1 selective inhibitor (C527) promotes the degradation of ID1 and induces cytotoxicity in leukemic cells [XREF_BIBR]."
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"Evidence shows that depletion of USP1 in either murine models or chicken DT40 cells enhances chromatin loading of the ID complex in the absence of exogenous DNA damage, but only to similar levels as observed following mitomycin C (MMC) treatment, suggesting the existence of alternative mechanisms to restrain ID complex loading at DNA lesions."
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