IndraLab

Statements

USP1 activates ID1. 16 / 16
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"These data suggest that ATAD5 regulates interactions between UAF1 and ID1 and this regulatory mechanism for ID1 is different from USP1 mediated ID1 regulation."
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"Collectively, these results indicate that the novel small molecule inhibitors of USP1 promote ID1 degradation and are cytotoxic to leukemic cells."
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"Here, we demonstrate that targeting USP1 with a small molecule, can promote ID1 degradation and cell death in multiple leukemic cell lines."
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"A doxycycline induced USP1 shRNA suppressed USP1 expression and reduced ID1 and ID2 in the xenografts."
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"Evidence shows that depletion of USP1 in either murine models or chicken DT40 cells enhances chromatin loading of the ID complex in the absence of exogenous DNA damage, but only to similar levels as observed following mitomycin C (MMC) treatment, suggesting the existence of alternative mechanisms to restrain ID complex loading at DNA lesions."
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"USP1 removes the polyubiquitin chains and rescues ID1 from degradation."
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"USP1 promotes ID protein stability."
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"USP1 knockdown specificity was confirmed with shRNA resistant USP1, which restored ID1, ID2, and ID3 to basal levels."
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"USP1 enhanced protein stability of the ID1 and CHEK1, important regulators of DNA damage response and stem cell maintenance (Lee et al., 2016)."
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"In contrast to USP1 knockdown, USP1 overexpression in primary human mesenchymal stem cells (hMSCs) caused ID protein accumulation and interfered with normal differentiation."
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"The small molecule inhibitor of USP1 promotes ID1 degradation and has cytotoxicity to leukemic cells [XREF_BIBR]."
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"More importantly , inhibition of USP1 leads to the downregulated expression of ID1 , further causing the inactivation of PI3K / AKT pathway ."
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"Besides DNA repair proteins, USP1 also promotes stabilization of ID (ID1-ID4) proteins 31."
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"Another USP1 selective inhibitor (C527) promotes the degradation of ID1 and induces cytotoxicity in leukemic cells [XREF_BIBR]."
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"We show that the deubiquitinating enzyme USP1 promotes ID protein stability and stem cell like characteristics in osteosarcoma."
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"A Previous study reported that overexpression of ubiquitin-specific protease 1 ( USP1 ) increases ID1 expression , leading to centrosome duplication [ 17 ] ."
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