IndraLab

Statements

Magnesium atom inhibits NFKB1. 4 / 4
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"High [Mg (2+)] (o) (i.e. 4.8 mM) downregulated p50 and p65."
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"Considering that NFkB-signaling represses reprogramming of mouse MG by promoting reactivity networks and anti-neurogenic factors, while increasing cell death in damage retinas (Palazzo et al., 2022), it is important to understand how different cell signaling pathways coordinate with NFkB to develop techniques to enhance neuronal survival and retinal regeneration."
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"Reactive microglia rapidly upregulate pro-inflammatory cytokines to damaged retinas (Todd et al., 2019), and these cytokines activate NFkB-signaling in MG which, in turn, suppresses the neurogenic potential of Ascl1-overexpressing MG (Palazzo et al., 2022)."
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"These results strongly suggest that NFkB activation by Mg deficiency is mediated by oxidant species.We utilized a protein array tailored for proteins involved in inflammation and atherogenesis to stud[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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