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"For instance, USP33 has been shown to be negatively regulated by p97, the p97 is responsible for HERC2-mediated polyubiquitination of USP33 (Chan et al. 2014), highlighting the HERC2-p97-axis-mediated ubiquitin-proteasome system (UPS) may be a potential target for USP33 degradation, which needs further investigation."