IndraLab

Statements

USP14 activates IL1B. 5 / 5
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"It has been reported that USP14 may up-regulate the production of pro-inflammatory cytokines through the NF-κB pathway 51, and USP14 may enhance the dedifferentiation effect of IL-1β on chondrocytes 52."
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"Finally, we provided gain-of-function evidence to further demonstrate that upregulation of USP14 promotes pyroptosis in AF cells by provoking NLRP3 activation and the productions of IL-1β and IL-18."
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"However, inhibition of USP14 activity with IU1, silencing of UCH37 with siRNA, or a combination of both approaches to inhibit both USP14 and UCH37 simultaneously did not inhibit the release of IL-1beta (XREF_FIG)."
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"Finally, USP14 promoted the dedifferentiation effect of IL-1β on chondrocytes, whereas inhibition of NF-κB remarkably reversed this effect, implying that NF-κB efficiently regulates the function of USP14 (Li M. et al., 2019)."
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"Overall, a feed-forward loop driven by NF-κB and USP14 in promoting the effect of IL-1β on chondrocytes might offer potential hints on therapeutic interventions for OA (Table 2)."
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