IndraLab

Statements


USP22 increases the amount of integrin b1. 4 / 4
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"Consistently, re-expression of WT USP22, but not its mutants restored integrin b1 expression in USP22-null breast cancer cells (Fig. 3N & 3O)."

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"USP22 promotes integrin b1 expression through FoxM1 stabilization.."

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"These results support our hypothesis that USP22 specifically promote integrin b1 expression through FoxM1 stabilization."

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"USP22 appears to positively regulate integrin b1 expression at the transcriptional level because its targeted deletion resulted in a more than 70% reduction in ITGB1 mRNA levels (Fig. 2E)."