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AP14145 inhibits KCNH2. 1 / 1

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"AP14145 inhibited hERG (K V 11.1) with an IC 50 of 71.8 +/-0.5 micromol/L and K ir 3.1/K ir 3.4 (I KACh) with an IC 50 of 9.3 +/-0.4 micromol/L and did not produce any significant effects on K V 1.5 (I Kur), K V 7.1/KCNE1 (I Ks), K V 4.3/KChiP2 (I to), and K ir 2.1 (I K1) in 30 micromol/L or on Na V 1.5 (15 micromol/L; I Na; Figure XREF_FIG, middle)."

29018164

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AP14145 inhibits KCNH2. 1 / 1

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