IndraLab

Statements

COPS5 inhibits CD274. 3 / 3

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"COP9 signalosome 5 ( CSN5 ) was reported to deubiquitinate PD-L1 , thereby inhibiting PD-L1 degradation ."

32467592

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"Disrupting the MPN domain of CSN5 affected CSN5 mediated PD-L1 stabilization and deubiquitination XREF_BIBR."

33354502

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"Additionally, inhibition of CDK4/6 by palbociclib upregulates and CSN5 by curcumin downregulates the stability of PD-L1, leading to increased therapeutic effect of anti-PD-1 and anti-CTLA-4 therapy, respectively."

31668929

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IndraLab

Statements

COPS5 inhibits CD274. 3 / 3

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