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This Service

A database built with INDRA combining content from numerous readers and databases. This page allows you to curate the loaded statements. For more information please see the manual.

This Project

INDRA is developed by indralabs, a part of the Harvard Medical School Laboratory of Systems Pharmacology.

This project, indra_db, is also developed by the indralab team. For more information on how we procure our sources, you can go here. This work was funded by ARO grant W911NF‐15‐1‐0544 under the DARPA Communicating with Computers program.

IndraLab

Statements

COPS5 inhibits CD274. 3 / 3

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"COP9 signalosome 5 ( CSN5 ) was reported to deubiquitinate PD-L1 , thereby inhibiting PD-L1 degradation ."

32467592

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"Disrupting the MPN domain of CSN5 affected CSN5 mediated PD-L1 stabilization and deubiquitination XREF_BIBR."

33354502

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"Additionally, inhibition of CDK4/6 by palbociclib upregulates and CSN5 by curcumin downregulates the stability of PD-L1, leading to increased therapeutic effect of anti-PD-1 and anti-CTLA-4 therapy, respectively."

31668929

Our Sources:

INDRA allows us to combine the results from a multitude of sources. In particular, the INDRA Database draws on the following...