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USP18 activates Parkinson Disease. 2 / 2
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"Taken together, these results provide evidence that USP18 inhibition may also decrease PD‐L1 expression to enhance the antitumor immune response.2.5 Genetic Effect of lncRNA BCCE4 on Bladder Tumors In Vivo."
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"Mechanistically, the lncRNA BCCE4 A allele loses a binding site for miR‐328‐3p, decreases USP18 expression levels by missing its function as a miRNA sponge, and thus downregulates PD‐L1 levels to restore the antitumour immune response in bladder cancer (Figure 5G)."
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