IndraLab

Statements


Hydroxychloroquine decreases the amount of TLR9. 5 / 6
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"Our findings showed that prednisolone and hydroxychloroquine may down-regulate levels of TLR7 and TLR9, respectively."

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"HCQ treatment reduced the protein levels of TLR9, MyD88, premature IL-1β and TNF-α and increased IL-10 abundance compared to the FMT group (Fig. 7E)."

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"In conclusion, prednisolone and TLR antagonist (hydroxychloroquine) may down-regulate expression levels of TLR7 and TLR9 in lupus patients, thereby decreasing the innate immune response to HPV infection."

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"IHC staining showed that TLR9 expression was increased in the placental tissues of rats in the HCQ group following FMT, whereas HCQ decreased TLR9 expression in the FMT group (Fig. 7D)."

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"In conclusion, prednisolone and TLR antagonist (hydroxychloroquine) may down-regulate protein levels of TLR7 and TLR9 in lupus patients, thereby decreasing the innate immune response against HPV infection."