IndraLab

"More interestingly, Plk3 also destabilizes SIAH2 in a kinase activity dependent manner.55 Thus, a mutual regulatory mechanism exists between Plk3 and SIAH2, which may functions to fine-tune the HIF-1 signaling.USP28, a deubiquitinase that suppresses the stability of MYC and HIF-1a,36,60,61 also appears to indirectly contribute to suppression of Plk3 by hypoxia and nickel.55 It has been shown that USP28 can be suppressed by nickel via HIF-, the ubiquitin-proteasome system-, and DNA methylation dependent mechanisms.62 USP28 prevents the suppression of Plk3 by nickel, suggests that suppression of Plk3 deubiquitination by USP28 in response to nickel could contribute to the elevated degradation of Plk3 by the ubiquitin-proteasome system."