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USP22 inhibits TP53. 31 / 33
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"Usp22 promotes oncogenic c-Myc activation as well as indirectly antagonizes the tumor-suppressive function of p53, and clearly diminishes tumor growth in in vitro and in vivo LLC1 models (55)."
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"USP22 Silencing Down-Regulates MDMX and Up-Regulates the p53 Pathway in NSCLC Cells."
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"In retinoblastoma, the depletion of USP22 has been shown to induce cancer cell apoptosis by suppressing the TERT/P53 signal pathway ."
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"High USP22 expression levels potently suppress the transcriptional activity of p53 that contributes to cancer cell proliferation and inhibition of apoptosis or senescence [6]."
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"Additionally, by deubiquitinating Sirt1, the increased expression of USP22 decreased the frequency of p53-dependent apoptosis and oxidative response (Figures 5, 6)."
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"USP22 can be inhibited by shRNA, activates the p53 pathway in tumours and downregulates MDMX protein, thereby inducing apoptosis in NSCLC cells (9)."
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"Collectively, our data indicates that USP22 inhibits p53 functions through Sirt1 deacetylase."
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"It has been reported that USP22 antagonizes p53 in bladder cancer cells through up-regulating MDM2 [XREF_BIBR]."
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"On the bases of these results, we speculated that USP22 silencing activates the p53 pathway in NSCLC cells by post-transcriptional down-regulation of MDMX."
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"As for Myc, USP22 depletion blocked the ability of p53 to activate the transcription of its targets."
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"Furthermore, USP7 plays key roles in the p53 tumor suppressor pathway through stabilization of p53 via increasing MDM2, the E3 ligase largely responsible for the ubiquitination of p53 [6, 52]; while USP22 is reported to antagonize p53 transcriptional activation by deubiquitinating Sirt1 which deacytatates p53 and reduces its transcriptional activity [34]."
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"Additionally, USP22 downregulates p53 and acts as a counterbalance against ferroptosis [ 175 ]."
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"USP22 can stabilize proteins, inhibit many TP53 host-protective functions and affect the DNA damage response [98, 99]."
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"Importantly, overexpression of MDMX reversed USP22 silencing, induced p53 activation, growth inhibition, cell cycle arrest and apoptosis in A549 cells (XREF_FIG B-E)."
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"USP22 may antagonize p53 through Sirt1 stabilization to suppress cell apoptosis under DNA damage and during embryonic development (Lin etal., 2012)."
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"Intriguingly, we found that USP22 silencing activates the p53 pathway in human NSCLC cells and tumor tissues along with downregulation of MDMX protein, a major negative regulator of p53."
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"USP22 may decrease levels of p53 through SIRT1 stabilization to suppress cell apoptosis during DNA damage and during embryonic development [ 14 ] ."
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"Collectively, our data indicate that USP22 deubiquitinates and stabilizes Sirt1 protein.Sirt1 has been reported to deacetylate p53 and suppress p53 transcriptional activation ( Vaziri et al., 2001; Yu[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"The results showed that upregulation of USP22 in the HeLa cell line resulted in increased expression of BMI-1, c-MYC and cyclin D2 ( Fig. 6 B, C, D ), but decreased expression of p53 ( Fig. 6 A)."
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"Because USP22 inhibits the ubiquitination-mediated Sirt1 degradation, we hypothesized that USP22 inhibits p53 functions through Sirt1."
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"As a consequence, USP22 inhibited p53-driven puma-luciferase activity in HCT116 cells that carry a wild-type p53 gene."
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"Therefore, USP22 appears to be critical for the early stages of embryonic development.Our findings so far support that USP22 functions as a critical antiapoptotic factor by facilitating Sirt1-mediated[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"USP22 suppresses cell apoptosis by inhibiting p53 functions in a SIRT1-dependent manner, while its anti-apoptotic effects are required for mouse embryonic development."
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"USP22 inhibits p53 activity and transcriptional activation of the p53 target gene by stabilizing SIRT1 through deubiquitination to suppress cell apoptosis [ 29 ]."
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"While the underlying molecular mechanisms are to be determined, our finding that USP22 suppresses p53 activity through Sirt1 stabilization suggests that increased p53 functions and cell apoptosis acco[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"A recent study uncovered that USP22 can repress the transcriptional activity of p53 to upregulate SLC7A11 expression, thereby suppressing ferroptosis in cardiomyocytes [28]."
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"Since Sirt1 is a suppressor for p53 functions, it is possible that USP22 promotes cell proliferation and suppresses apoptosis through regulation of Sirt1 to antagonize p53 function."
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"Downregulation of USP22 by siRNA in the HeLa cell line resulted in the decreased expression of BMI-1, c-MYC and cyclin D2 ( Fig. 3 B, C, D) and increased expression of p53 ( Fig. 3 A)."
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"Hence USP22 silencing reduces the capacity of FBP1 to repress p21 (independently of TP53 status), which in turn inhibits CDKs to prevent the G1/S transition and resulting in G1 accumulation [XREF_BIBR]."
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"Several studies demonstrated that USP22 silencing could activate p53."
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"Because USP22 inhibits the ubiquitination-mediated Sirt1 degradation, we hypothesized that USP22 inhibits p53 functions through Sirt1."
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