IndraLab

Statements


USP22 inhibits TP53. 11 / 13
| 1 10

reach
"Intriguingly, we found that USP22 silencing activates the p53 pathway in human NSCLC cells and tumor tissues along with downregulation of MDMX protein, a major negative regulator of p53."

reach
"USP22 Silencing Down-Regulates MDMX and Up-Regulates the p53 Pathway in NSCLC Cells."

reach
"It has been reported that USP22 antagonizes p53 in bladder cancer cells through up-regulating MDM2 [XREF_BIBR]."

reach
"Hence USP22 silencing reduces the capacity of FBP1 to repress p21 (independently of TP53 status), which in turn inhibits CDKs to prevent the G1/S transition and resulting in G1 accumulation [XREF_BIBR]."

reach
"As for Myc, USP22 depletion blocked the ability of p53 to activate the transcription of its targets."

reach
"In retinoblastoma, the depletion of USP22 has been shown to induce cancer cell apoptosis by suppressing the TERT/P53 signal pathway ."

reach
"Importantly, overexpression of MDMX reversed USP22 silencing, induced p53 activation, growth inhibition, cell cycle arrest and apoptosis in A549 cells (XREF_FIG B-E)."

reach
"Several studies demonstrated that USP22 silencing could activate p53."

reach
"On the bases of these results, we speculated that USP22 silencing activates the p53 pathway in NSCLC cells by post-transcriptional down-regulation of MDMX."

reach
"USP22 may antagonize p53 through Sirt1 stabilization to suppress cell apoptosis under DNA damage and during embryonic development (Lin etal., 2012)."

eidos
"USP22 may decrease levels of p53 through SIRT1 stabilization to suppress cell apoptosis during DNA damage and during embryonic development [ 14 ] ."