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USP18 activates regulation of cell cycle. 3 / 3
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"Then, we explored the effect of USP18 on paclitaxol-induced cell cycle arrest in TNBC cells."
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"We further showed that USP18 could reduce paclitaxol sensitivity, and attenuate paclitaxol-induced apoptosis and cell cycle arrest through activating autophagy in TNBC cells in vitro and in vivo ."
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"Cell apoptosis and cell cycle assays also showed that leupeptin abrogated the effect of USP18 on paclitaxol-induced cell apoptosis and cell cycle arrest in MDA-MB-231 cells ( Fig. 3 D&E)."
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