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UCHL3 inhibits Radiation, Ionizing. 3 / 3
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"In addition, since the increased sensitivity to IR caused by UCHL3 depletion was moderate and the human genome encodes around 100 DUBs, it would be interesting to examine if any other DUBs can deubiquitylate Ku."
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"To exclude the possibility that the increased IR sensitivity caused by UCHL3 depletion was due to decreased proliferation or cell cycle issues, cell proliferation and cell cycle profile of these cell lines were examined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT)-based assay and bromodeoxyuridine (BrdU) incorporation assay, respectively (Supplementary Fig. S2A,B)."
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"Finally, re-expression of wild-type UCHL3 but not the S75A mutant was able to reverse hypersensitivity to IR induced by UCHL3 deficiency (Fig. 5F)."
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