IndraLab

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CAV1 inhibits KCNH2. 2 / 3
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"The CAV1 protein colocalizes with and negatively regulates the activity of KCNH2, a potassium channel involved in cardiac repolarization; the corresponding KCNH2 gene was found to be associated with atrial fibrillation in a candidate gene association study, although not in our present analysis 14."
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"Compounds 1-3 displayed activity as cardiac calcium channel blockers (Cav1.2) but did not inhibit the hERG potassium channel and were not cytotoxic."
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