IndraLab

Statements

USP15 binds FKBP*. 6 / 6
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sparser
"Similarly, mutant FKBP*-USP15(C298A) levels were about 19% of that in vehicle-treated cells, compared to 65 % for the wild-type construct."
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sparser
"For FKBP*-USP15 and FKBP*-UCHL1, protein levels of dTAG-13-treated cells were about 65 % and 47 % that of vehicle-treated cells respectively ( xref and xref )."
40661558
sparser
"For FKBP*-USP15(C298A), protein levels were about 27 % of that in vehicle-treated cells compared to about 85 % for wild-type FKBP*-USP15."
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sparser
"Both FKBP*-USP4 and FKBP*-USP15 levels were greater than 80 % that of vehicle-treated cells after two hours, in stark contrast to the rapid degradation of FKBP*-USP11."
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"After 24 hours, FKBP*-USP4, FKBP*-USP15 and FKBP*-UCHL1 levels had dropped to around 9 %, 23 % and 28 %, respectively, of that observed in vehicle-treated cells ( xref – xref )."
40661558
sparser
"To investigate whether the less robust degradation of USP4, USP15 and UCHL1 was due to auto-deubiquitylation, we made mutant constructs in which the catalytic cysteine was replaced with a serine or alanine residue (FKBP*-USP4(C311S), FKBP*-USP15(C298A) and FKBP*-UCHL1(C90A))."
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