IndraLab

Statements

USP6 binds EIF5A. 3 / 3
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"Physiological ex vivo models are important tools for basic and translational research and as these models slowly get integrated into functional precision oncology approaches and clinical decision-making processes, it is of utmost importance that they represent the native tumor from a genotype and phenotype standpointIn the primary tumor, the dermal metastasis and the corresponding ex vivo cell model (USZ20.-ESOS1), an in-frame EIF5A::USP6 fusion was detected."
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"EIF5A::USP6 fusion was found in the case of late adolescent female with superficial nodular fasciitis of the forearm region."
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"Both the sarco-sphere model as well as the corresponding tumor tissue harbored an in-frame EIF5A::USP6 fusion in chromosome 17, homozygous losses of CDKN2A/B and ATRK , a truncation in the NOTCH1 gene and a TCF3::SLC39A3 rearrangement."
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