IndraLab

Statements

Minocycline inhibits MAPK8. 3 / 3
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"Minocycline inhibited JNK1/2 and ERK1/2 but not p38 when stimulated by 2',3'-O-(4-benzoylbenzoyl)-adenosine 5'-triphosphate, indicating that minocycline affects only certain upstream signaling target(s) that are stimulus-specific."
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"Here, we found p-p38, p-JNK was significantly reduced by minocycline, which might correlate to the inhibited M1 subtype polarization."
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"A subnetwork for the three most relevant kinases with the indication of functional phosphorylations (black font) is shown in xref A . While PAK2 and CDK1 can be targeted by the tyrosine kinase inhibitor fostamatinib, JNK1 can be inhibited by tamoxifen and minocycline."
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