IndraLab

Statements

OTUB2 binds PKM2. 7 / 7
| 7
sparser
"OTUB2 binds to PKM2 and inhibits its ubiquitination by obstructing its interaction with E3 ubiquitin ligase Parkin, thus augmenting PKM2 activity and facilitating glycolysis in colorectal cancer cells [ xref ]."
40849293
sparser
"The deubiquitinase OTUB2 directly binds to PKM2, preventing its interaction with the E3 ubiquitin ligase Parkin, thereby stabilizing PKM2 and enhancing its enzymatic activity by blocking ubiquitination and degradation."
40842995
sparser
"OTUB2 directly interacts with PKM2 to inhibit its ubiquitination by disrupting the interaction between PKM2 and E3 ubiquitin ligase Parkin, thus enhancing its pyruvate kinase activity and promoting the Warburg effect [ xref ]."
40137167
sparser
"Moreover, the deubiquitinase OTUB2 directly interacts with PKM2 and inhibits its ubiquitination, resulting in enhanced glycolysis, proliferation and migratory capacity in CRC cells [ xref ]."
39993964
sparser
"OTUB2, an OTU deubiquitinase, directly interacts with PKM2 and suppresses its ubiquitination via weakening the interaction of PKM2 and Parkin to increase PKM2 activity and glycolysis in colorectal cancer ( xref )."
38910890
sparser
"In colon cancer, OTUB2 interacts with PKM2, enhancing its activity and promoting glycolysis, thereby facilitating colorectal cancer progression [ xref ]."
39380010
sparser
"PKM2 directly interacts with OTUB2, an OTU deubiquitinase overexpressed in CRC, inhibiting its ubiquitination by blocking the interaction between PKM2 and the ubiquitin E3 ligase Parkin."
40884151