IndraLab

Statements

OTUB2 binds PKM2. 4 / 4
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sparser
"OTUB2 directly interacts with PKM2 to inhibit its ubiquitination by disrupting the interaction between PKM2 and E3 ubiquitin ligase Parkin, thus enhancing its pyruvate kinase activity and promoting the Warburg effect [ xref ]."
40137167
sparser
"OTUB2, an OTU deubiquitinase, directly interacts with PKM2 and suppresses its ubiquitination via weakening the interaction of PKM2 and Parkin to increase PKM2 activity and glycolysis in colorectal cancer ( xref )."
38910890
sparser
"In colon cancer, OTUB2 interacts with PKM2, enhancing its activity and promoting glycolysis, thereby facilitating colorectal cancer progression [ xref ]."
39380010
sparser
"Moreover, the deubiquitinase OTUB2 directly interacts with PKM2 and inhibits its ubiquitination, resulting in enhanced glycolysis, proliferation and migratory capacity in CRC cells [ xref ]."
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