IndraLab

Statements

Ubiquitin inhibits OTULIN. 2 / 2
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"Deficiency of the linear ubiquitin chain-specific deubiquitinase, OTULIN, causes OTULIN-related autoinflammatory syndrome (ORAS), a systemic inflammatory pathology affecting multiple organs including the skin."
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"Consistently, mutation of the proximal ubiquitin Glu16 to alanine (E16A) reduces the catalytic efficiency (k cat) of OTULIN by 240-fold without significantly affecting binding of the substrate (similar K D and only 3-fold reduction in K M) [XREF_BIBR]."
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