IndraLab

Statements

USP1 activates ID2. 3 / 3
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"Mechanistically, we found that PDGF signaling regulated the expression of the E2F transcription factors, which directly bound to and activated Usp1 Furthermore, PDGF mediated expression of USP1 led to the stabilization of Inhibitor of DNA binding 2 (ID2), which we found to be required for glioma cell survival."
26951930
reach
"USP1 knockdown specificity was confirmed with shRNA resistant USP1, which restored ID1, ID2, and ID3 to basal levels."
21925315
reach
"A doxycycline induced USP1 shRNA suppressed USP1 expression and reduced ID1 and ID2 in the xenografts."
21925315