IndraLab

Statements

USP15 binds PARP1. 12 / 12
5 | 2 5
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"Two PARP1 mutations found in individuals with breast cancer (E90K and S104R) enhanced the PARP1-USP15 interaction and suppressed PARP1 ubiquitination, thereby elevating the protein level of PARP1."
37012401
biogrid
No evidence text available
37012401
biogrid
No evidence text available
37012401
biogrid
No evidence text available
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biogrid
No evidence text available
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reach
"Here, we demonstrated that the deubiquitinase USP15 interacts with and deubiquitinates PARP1 to promote its stability, thereby stimulating DNA repair, genomic stability and TNBC cell proliferation."
37012401
sparser
"ER binds to the USP15 promoter to suppress its expression, PR inhibits the deubiquitinating enzyme activity of USP15, and HER2 disrupts the PARP1–USP15 interaction (Figure  xref )."
40904702
biogrid
No evidence text available
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reach
"For example, the deubiquitinase USP15 interacts with and deubiquitinates PARP1, promoting its stability and thereby stimulating DNA repair, genomic stability, and the proliferation of triple‐negative breast cancer cells."
39329019
sparser
"Additionally, a previous study has shown that USP15 can interact with PARP1 [ xref ]."
40151951
sparser
"Two PARP1 mutations (E90K and S104R) found in breast cancer enhance the interaction between PARP1 and USP15 and inhibit PARP1 ubiquitination, leading to abnormally elevated PARP1 levels."
40904702
sparser
"ER bound to the USP15 promoter to suppress its expression, PR suppressed the deubiquitinase activity of USP15, and HER2 abrogated the PARP1-USP15 interaction."
37012401