IndraLab

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Pyraclofos activates SCN4A. 4 / 4
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"Depolarization during muscle action potentials is driven by opening of voltage-activated Nav1.4 channels, and subsequent repolarization is driven by the voltage-activated K + channels xref , xref ."
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"Interestingly, we found that T592I induced a left shift of Nav1.4 activation voltage dependence resulting in larger window currents, similarly to I558V."
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"To study voltage dependent activation of SkM1 and SCN5A currents in GFP positive cMSC (n = 8/group), cells were held at -100 mV to prevent inactivation, and then pulsed to test potentials from -80 to +40 mV, with 5 mV increments (XREF_FIG)."
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"We first measured the voltage dependent activation of SkM1 and SCN5A current in GFP positive cells (XREF_FIG)."
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