IndraLab

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USP22 activates Neoplasm Metastasis. 29 / 30
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"These data demonstrate that USP22 promotes in vivo GC growth and metastasis."
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"USP22 may promote tumor progression and metastasis."
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"We found that the USP22 expression increased significantly from normal mucosa to carcinomas and from carcinomas to lymph node metastasis."
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"As expected , downregulation of USP22 suppressed OS tumor growth and metastasis in vivo ."
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"USP22 stimulates CRC cell metastasis in vivo."
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"The USP22 increases growth and metastasis of HCC cells via inducing Wnt/β-catenin signaling."
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"Moreover, USP22 and AP4 overexpression may stimulate tumor metastasis and adversely affect OS in CRC patients."
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"These results suggest that USP22 downregulation inhibited OS tumor growth and metastasis in vivo ."
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"In vivo, elevated USP22 expression promotes CRC cell metastasis to the lungs in nude mice, as evidenced by the fact that CRC metastatic nodules stain deeply positive for USP22 and AP4."
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"Here, we propose a novel mechanism by which USP22 drives CRC progression and metastasis."
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"USP22 knockdown reduces the invasiveness and metastasis of multiple cancers by downregulating pathways driven by the oncoprotein, BMI-1 [27, 29, 33]."
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"In vivo experiments reveal that USP22 knockdown in GC cells significantly reduces xenograft tumor growth and lung metastasis in SCID mice."
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"However, the mechanism by which USP22 promotes CRC metastasis remains largely unknown."
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"Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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"Moreover, USP22 overexpression can promote EMT and TGF-beta expression, whereas USP22 knockdown can reverse EMT and reduce the metastasis of lung adenocarcinomas."
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"In stomach cancer, USP22 abundance increased from normal tissue to primary carcinoma to lymph node metastasis and was also associated with shorter patient survival (26 vs. 59 months disease specific survival for USP22 positive vs. -negative primary carcinoma) [XREF_BIBR]."
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"These findings suggest that AP4 may be involved in USP22 driven CRC progression and metastasis."
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"USP22 depletion attenuates in vivo GC growth and metastasis."
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"In addition , downregulation of USP22 suppressed OS tumor growth and metastasis in vivo ."
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"These results suggest that USP22 promotes tumor development and metastasis, and highlight USP22 as a novel prognostic marker and potential therapeutic target in ATC."
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"Downregulation of USP22 reduces in vitro cancer cell proliferation, survival, migration, and invasion, and decreases in vivo tumor growth and metastasis [6, 10–13]."
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"These findings indicate that USP22 promotes CRC invasion and metastasis by inducing EMT via AP4 activation."
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"These results lend further support to the results of our vitro experimental studies, as they showed that USP22 promotes CRC cell metastasis by activating AP4 to induce EMT."
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"We subsequently revealed that USP22 up-regulation in poorly metastatic cells can promote CRC cell metastasis to the lungs in nude mouse models."
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"These results demonstrate that USP22 and AP4 may promote tumor progression and metastasis and imply that their expression leads to poor outcomes in CRC."
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"Previous reports showed that USP22, another ubiquitin specific protease, promotes tumor invasion and metastasis 33, 34."
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"The USP22 expression increased significantly from non cancerous mucosa to carcinomas (P < 0.001) and from carcinomas to lymph node metastasis (P < 0.001) (XREF_FIG)."
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"In implantation xenografts, USP22 overexpression stimulated tumour growth and metastasis to the lungs of mice."
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