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USP22 activates Neoplasm Metastasis. 63 / 64
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"These findings suggested that USP22 promotes melanoma metastasis both in vitro and in vivo.2.3 Elevated USP22 induces EMT activation in melanoma."
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"USP22 knockdown reduces the invasiveness and metastasis of multiple cancers by downregulating pathways driven by the oncoprotein, BMI-1 [27, 29, 33]."
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"Oncogenic USP22 supports gastric cancer growth and metastasis by activating c-Myc/NAMPT/SIRT1-dependent FOXO1 and YAP signaling."
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"The USP22 increases growth and metastasis of HCC cells via inducing Wnt/β-catenin signaling."
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"These results demonstrated that USP22 might promotes melanoma metastasis by inducing EMT activation.2.4 USP22 potentiates melanoma metastasis and EMT through activating PI3K/Akt/mTOR pathway."
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"In addition, USP22 silencing blocks OS tumour growth and metastasis in vivo ."
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"Meanwhile, USP22 is reported to promote GC distant metastasis (9, 10, 23)."
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"Downregulation of USP22 reduces in vitro cancer cell proliferation, survival, migration, and invasion, and decreases in vivo tumor growth and metastasis [6, 10–13]."
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"USP22 knockdown reduces T cell-dependent tumor metastasis, increases the immunogenicity of tumors, increases the lymphatic invasion of tumors and natural killer cell activity [ 82 ], and enhances anti[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Both genetic and pharmacological inhibition of USP22 largely impaired breast CSCs self-renewal and prevented their metastasis."
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"Knockdown of USP22 reduces metastasis in human colon cancer cells."
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"These results suggested that USP22 potentiates melanoma metastasis and EMT through activating the PI3K/Akt/mTOR pathway.2.5 USP22 activates PI3K/Akt/mTOR pathway via SIRT1/PTEN axis."
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"These results suggest that USP22 promotes metastasis in human colon cancer cells."
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"USP22 facilitated EPI-induced breast cancer progression and metastasis by enhancing adipose triglyceride lipase (ATGL)-mediated lipolysis."
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"Therefore, Bmi-1 and Cyclin D2 may be involved in the promotion of proliferation and metastasis of colon cancer cells by USP22."
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"Our discovery that genetic USP22 deletion hindered breast BCSCs self-renewal and inhibited their lung metastasis provides a rationale for USP22 targeting in anticancer therapy."
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"We subsequently revealed that USP22 up-regulation in poorly metastatic cells can promote CRC cell metastasis to the lungs in nude mouse models."
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"Both genetic and pharmacological USP22 inhibition largely impaired breast cancer stem cell self-renewal and prevented their metastasis."
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"These results lend further support to the results of our vitro experimental studies, as they showed that USP22 promotes CRC cell metastasis by activating AP4 to induce EMT."
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"USP22 inhibition abolished EPI-induced breast cancer metastasis."
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"The USP22 expression increased significantly from non cancerous mucosa to carcinomas (P < 0.001) and from carcinomas to lymph node metastasis (P < 0.001) (XREF_FIG)."
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"Moreover, USP22 overexpression can promote EMT and TGF-beta expression, whereas USP22 knockdown can reverse EMT and reduce the metastasis of lung adenocarcinomas."
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"We found that the USP22 expression increased significantly from normal mucosa to carcinomas and from carcinomas to lymph node metastasis."
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"USP22 plays as an interactor with LINC01426 and activates the hedgehog pathway to promote the invasion and metastasis in lung adenocarcinoma via stabilizing SHH protein [ 48 ]."
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"In this study, we demonstrate that the ubiquitin-specific peptidase 22 (USP22) is essential for HGF-induced melanoma metastasis."
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"However, the mechanism by which USP22 promotes CRC metastasis remains largely unknown."
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"In implantation xenografts, USP22 overexpression stimulated tumour growth and metastasis to the lungs of mice."
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"Similarly, intravenous injection of 4T1 cells showed that suppressing USP22 entirely nullified the EPI-induced enhancement in TNBC metastasis (Fig. 2, V to Y)."
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"Our discovery that genetic USP22 deletion hindered breast cancer stem cell self-renewal and inhibited their lung metastasis provides a rationale for USP22 targeting in anticancer therapy."
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"Moreover, USP22 and AP4 overexpression may stimulate tumor metastasis and adversely affect OS in CRC patients."
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"Pharmacological inhibition of USP22 by topotecan exerts a similar effect to USP22 knockout in inhibiting melanoma metastasis both in vivo and in vitro."
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"In stomach cancer, USP22 abundance increased from normal tissue to primary carcinoma to lymph node metastasis and was also associated with shorter patient survival (26 vs. 59 months disease specific survival for USP22 positive vs. -negative primary carcinoma) [XREF_BIBR]."
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"These findings suggest that AP4 may be involved in USP22 driven CRC progression and metastasis."
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"In fact, pharmacological USP22 inhibition dramatically reduced the frequency of breast cancer stem cells and attenuated both mouse and human invasive breast cancer lung metastasis."
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"Based on our results, the ferroptosis inhibitor liproxstatin‐1 partially rescued the inhibitory effect of topotecan on metastasis, indicating that pharmacological inhibition of USP22 could partially suppress melanoma metastasis by enhancing ferroptosis sensitivities.Previously, Yi et al. 53 revealed that activating mutations in PI3K or loss of PTEN mediate the ferroptosis resistance of cancer cells."
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"USP22 stimulates CRC cell metastasis in vivo."
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"Here, we propose a novel mechanism by which USP22 drives CRC progression and metastasis."
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"Moreover, inhibition of USP22 reduced osteosarcoma tumor growth and metastasis in mice (28)."
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"In vivo experiments reveal that USP22 knockdown in GC cells significantly reduces xenograft tumor growth and lung metastasis in SCID mice."
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"Previous reports showed that USP22, another ubiquitin specific protease, promotes tumor invasion and metastasis 33, 34."
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"USP22 in PC cells interacts with SAGA/STAGA to affect the immune microenvironment, and USP22 deficiency promotes T-cell and NK cell infiltration and inhibits tumor metastasis (116)."
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"Herein, we conducted RNA sequencing and found that USP22 promotes melanoma metastasis through the PI3K/Akt pathway."
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"These results reinforce our initial conclusion that USP22 plays a critical role in EPI-mediated breast cancer progression and metastasis."
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"These results demonstrate that USP22 and AP4 may promote tumor progression and metastasis and imply that their expression leads to poor outcomes in CRC."
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"USP22 depletion attenuates in vivo GC growth and metastasis."
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"These data demonstrate that USP22 promotes in vivo GC growth and metastasis."
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"In vivo, elevated USP22 expression promotes CRC cell metastasis to the lungs in nude mice, as evidenced by the fact that CRC metastatic nodules stain deeply positive for USP22 and AP4."
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"USP22 may promote tumor progression and metastasis."
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"Collectively, our study revealed a previously unappreciated molecular mechanism underlying how USP22 controls EPI-induced cancer progression and metastasis through potentiating FOXO1-medited ATGL expression and lipolysis."
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"These results suggest that USP22 promotes tumor development and metastasis, and highlight USP22 as a novel prognostic marker and potential therapeutic target in ATC."
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"USP22 maintained GC cell stemness by stabilizing BMI1 and promoted proliferation and metastasis by activating the FOXO1 and YAP signaling pathway [47,50]."
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"Collectively, our study revealed a previously unknown tumorigenic metabolic pathway, EPI/AKT/USP22/FOXO1/ATGL lipolysis in breast cancer progression and metastasis, and USP22 inhibition synergizes with β-blocker to inhibit breast cancer growth and lung metastasis (Fig. 7P)."
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"In addition , downregulation of USP22 suppressed OS tumor growth and metastasis in vivo ."
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"Overexpression of USP22 restored the inhibitory effect of miR-132-3p on CRC cell proliferation and metastasis."
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"Therefore, USP22-mediated stabilization of FOXO1 may promote breast cancer metastasis possibly through multiple cellular and molecular mechanisms."
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"These findings indicate that USP22 promotes CRC invasion and metastasis by inducing EMT via AP4 activation."
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"These results suggest that USP22 downregulation inhibited OS tumor growth and metastasis in vivo ."
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"Ubiquitin-specific peptidase 22 promotes proliferation and metastasis in human colon cancer."
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"Ablation of USP22 expression remarkably attenuates melanoma migration, invasion, and epithelial-mesenchymal transition in vitro and suppresses melanoma metastasis in vivo."
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"As expected , downregulation of USP22 suppressed OS tumor growth and metastasis in vivo ."
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"Our study also shows that USP22 silencing in GC cells decreases cell proliferation and induces cell cycle arrest and apoptosis in vitro, and suppresses tumor growth and metastasis in vivo."
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"Therefore, USP22 promoted both cell proliferation and cell metastasis in colon cancer cells and upregulation of USP22 predicted poor prognosis for patients with colon cancer.USP22 belongs to the deubiquitinase family of proteins and strictly regulates gene expression through histone deubiquitination or acetylation procession (12,13,15,16)."
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"In summary, USP22 downregulation reduces cancer cell proliferation, migration, and invasion and reduces tumor growth and metastasis in vivo."
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