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STAMBPL1 activates HYCC1. 5 / 5
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"These findings highlight the diverse roles that deubiquitinases play in HCC, either by promoting or suppressing the disease, and suggest that they could be potential targets for therapeutic intervention in HCC.In the study, we identified one oncogene gene (STAMBPL1) which promote the proliferation and metastasis of HCC."
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"Through the analysis of TCGA expression symbol and clinicopathological information, it was found that the expression of STAMBPL1 increased with the variation of tumor stage (Fig. 1K) and grade (Fig. 1M) in HCC."
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"Additionally, the EDU staining also demonstrated that suppression of STAMBPL1 expression could reduce the proportion of proliferative HCC cells (Fig. 3I, J)."
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"Additionally, the EDU staining also demonstrated that overexpression of STAMBPL1 expression could enhance the proportion of proliferative HCC cells (Fig. 4G)."
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"Functionally, STAMBPL1 significantly promoted HCC cells proliferation and metastasis, and it interacts with TRAF2 and stabilize it via the deubiquitination at the K63 residue."
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