IndraLab

Statements

USP7 inhibits FOXP3. 4 / 4
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"Combined USP7 and USP44 knockdown, however, even further enhanced FOXP3 degradation (Fig XREF_FIG D, left panel)."
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"However, in both Treg cell types, pre-treatment with SorA did not influence ubiquitin-mediated loss of FoxP3 protein induced by USP7 inhibition (Figure S4D, F)."
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"By modulating Foxp3 and Tip60, a prior research found that genetic or pharmacologic targeting of USP7 may block the inhibitory activities of Foxp3 Tregs and preserve normal T cell responses, reducing tumor development and enhancing the efficiency of anti-PD-1 monoclonal antibodies.98 Therefore, the further development and clinical testing of USP7 inhibitors combined with PD-L1/PD-1 checkpoint inhibitors may provide a new valuable approach for cancer immunotherapy."
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"The impact of these regulatory mechanisms in vivo , under both homeostatic and inflammatory conditions, await the generation of Treg cell-specific Usp7 , Stub1 , or HSP70 deficient murine models.Sever[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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