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Curcumin inhibits NFKBIA. 16 / 16
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"Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis."
12393461
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"Since the first report from our laboratory in 1995 that curcumin can inhibit activation of the proinflammatory transcription factor NF-kappaB by inhibiting the 26S proteasomal degradation of IkappaBalpha, an inhibitor of NF-kappaB, this yellow pigment has been shown to inhibit the protease activities of the proteasome."
23834173
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"Curcumin inhibits the IkappaBalpha degradation , phosphorylation of IkappaB serine 32 to block the cytokine-mediated NF-kappaB activation and thus pro-inflammatory gene expression ( Jobin et al ., 1999 ) ."
32596244
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"Next, we examined whether inhibition of IL-1beta-induced IkappaBalpha degradation was through inhibition of IkappaBalpha phosphorylation, the tenocytes were treated with curcumin and then with IL-1beta and examined for IkappaBalpha phosphorylation in the cytoplasm by Western blot analysis."
21669872
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"The molecular analysis of curcumin induced macrophage polarization demonstrated that curcumin inhibits the M1 macrophage phenotype by inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and by activating IkappaBalpha, and by promoting the M2 phenotype through the activation of proliferator activated receptor gamma (PPAR-gamma)."
28197150
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"As demonstrated in Figure XREF_FIG, curcumin suppressed IL-1beta-induced activation of Ikappa-Balpha in MSCs."
20594343
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"Curcumin prevents the degradation of IkappaBalpha , which inhibits the NF-kappaB transcription factor 109 ."
33995644
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"To test the effect of curcumin and HCWE on TNFalpha induced IkappaBalpha degradation, HeLa 229 cells were treated with curcumin (10muM) or HCWE (450mug/ml) for 2h, then stimulated with 1ng/ml TNFalpha for 20min."
21951655
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"Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis."
12393461
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"In addition, curcumin on COX-2 downregulation is mediated through NF-κB. Curcumin has been shown to inhibit activation of NF-κB that suppresses IKK which inhibits phosphorylation and degradation of IkB-kinase alpha (IkBa) followed by p65 nuclear translocation [92]."
31817718
eidos
"Curcumin prevents IKBalpha ( nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor , alpha ) phosphorylation and therefore inhibits NF-KB ( nuclear factor kappa-light-chain-enhancer of activated B cells ) [ 14 ] ."
34466459
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"Western blotting of total cell lysates to measure protein expression of phosphorylated p65 (p-p65) and IkappaBalpha (p- IkappaBalpha) revealed that curcumin treatment rapidly suppressed p-p65 and p-IkappaBalpha, but this effect was negligible after 30 and 60 min (XREF_FIG)."
25369140
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"Moreover, curcumin significantly inhibited PMA induced p-ERK, p-p38, p-JNK, p-Ikappa-Balpha and NF-kappaB."
26507910
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"A recent study suggests that the curcumin derivative EF24 suppresses NF-kappaB activation by directly inhibiting the degradation of I-kappa-B-alpha [XREF_BIBR], the inhibitory cytosolic subunit of NF-kappaB, whose phosphorylation and subsequent degradation is a prerequisite for activation of the NF-kappaB pathway."
27401816
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"Curcumin but not resveratrol inhibits IL-1beta-induced IkappaBalpha kinase activation."
19889203
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"Consistent with our data, curcumin was shown to inhibit the activation of NF-kappaB, Bharat et al. has reported curcumin down-regulates the constitutive activation of NF-kappaB and IkappaBalpha kinase in human multiple myeloma cells."
28261097