IndraLab

Statements

CYLD inhibits Cell Survival. 7 / 10
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"We observed that the overexpression of CYLD significantly reduced cell viability in PC-3 cells ( Fig. 4 F)."
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"Furthermore, cell viability assessed by MTS assay was also suppressed by overexpressed CYLD (20% inhibition; P < 0.05, compared with control), but not by catalytically inactive CYLD."
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"The results indicated that cell viability of Huh-7 and HepG2 cells was inhibited by EAC and EACG (Figures xref )."
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"Interestingly, CYLD deficiency has been shown to promote PCa cell proliferation, cell survival, and tumorigenesis, and CYLD abundance is reduced in advanced-stage PCa samples, suggesting that CYLD may play a tumour-suppressive role in PCa [13]."
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"In T cell acute lymphoblastic leukemia (T-ALL), CYLD expression is repressed by the Notch and Hes1 pathway to promote persistent IKK activation and cell survival [XREF_BIBR]."
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"Loss of CYLD in different types of tumors leads to either cell survival or proliferation."
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"Reduced expression of CYLD promotes cell survival and inflammation in gefitinib treated NSCLC PC-9 cells : targeting CYLD may be beneficial for acquired resistance to gefitinib therapy."
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