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Arachidonic acid inhibits KCNH2. 5 / 5
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"PAUL AA, WITCHEL HJ, HANCOX JC : Inhibition of HERG potassium channel current by the Class Ia antiarrhythmic agent disopyramide."
16706679
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"At 10 microM, AA and DHA blocked HERG channels, at the end of 5-s pulses to -10 mV, to a similar extent (37.7 +/- 2.4% vs. 50.2 +/- 8.1%, n = 7-10, P> 0.05)."
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"The large inner cavity of the hERG K + channels allows several molecules to enter and prevent potassium conduction denoting unique properties that make them an important, “promiscuous” drug binding si[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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"Finally, both AA and DHA induced a use dependent inhibition of HERG channels."
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"In addition, DHA and arachidonic acid inhibit human ether-a-go-go -related gene (HERG) channels ( Guizy et al., 2005 )."
19318040