IndraLab

Statements

USP25 inhibits TRAF3. 5 / 5
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"The following qPCR primer sequences were used: mouse USP25, forward 5’-AGGTACATCAGCGTGGGAAG-3′, reverse 5’−CCTGAATGCCCTGTTTGACT-3′; mouse TRAF3, forward 5’-TCAGGAAATTTGCCTATTGAAAATTT-3′, reverse 5’-GC[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30579117
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"Taken together, these data suggest that without USP25, KCs lost the ability to tolerate endotoxin and secreted a large amount of proinflammatory cytokines.Previously, we observed that USP25 suppressed[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
30579117
eidos
"] USP25 interacts with TRAF3 and TRAF6 following RNA virus or DNA virus infection and prevents TRAF3 and TRAF6 from proteasomal degradation via deubiquitinating K48-linked polyubiquitin chains ."
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"We found overexpression of USP25 indeed decreased TRAF3 K48 linked ubiquitination."
27026194
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"Several studies showed that USP25 negatively regulates virus-induced type I IFN signaling by stabilizing TRAF2, TRAF3 and TRAF6 [64,65,75,87,121,122,123,124]."
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