IndraLab

Statements

USP25 inhibits TRAF3. 3 / 3
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eidos
"] USP25 interacts with TRAF3 and TRAF6 following RNA virus or DNA virus infection and prevents TRAF3 and TRAF6 from proteasomal degradation via deubiquitinating K48-linked polyubiquitin chains ."
33511009
reach
"Several studies showed that USP25 negatively regulates virus-induced type I IFN signaling by stabilizing TRAF2, TRAF3 and TRAF6 [64,65,75,87,121,122,123,124]."
32650621
reach
"We found overexpression of USP25 indeed decreased TRAF3 K48 linked ubiquitination."
27026194