IndraLab

Statements

USP28 increases the amount of MYC. 4 / 4
| 4
reach
"Moreover, USP28 positively regulated the protein level of c-Myc, and c-Myc negatively regulated the radiosensitivity of ECA109 and ECA109R cells."
30206969
reach
"Similarly, USP28 is a DUB that stabilizes the c-Myc transcription factor, a potent oncogene in a wide variety of human cancers, and inhibiting USP28 is expected to reduce the levels of c-Myc, and downregulate its activities (Weisberg et al., 2017; Wrigley et al., 2017; Zhou et al., 2018)."
35737447
reach
"Importantly, USP28 WT remarkably increased protein expression of MYC, whereas USP28 Mut reversed lactate induced MYC and SLUG (XREF_FIG)."
30688660
reach
"USP28 WT but not CA mutant also enhanced levels of c-Myc and mature SREBP1a (Fig. S3c, d), indicating a similar mode of regulation."
37202505