IndraLab

Statements

Ezogabine inhibits KCNQ2. 3 / 8
5 | 3
reach
"When interacting with W265 by hydrogen bonding, utilizing its carbonyl oxygen as an H-bond acceptor (27), retigabine is able to negative-shift the voltage dependence of KCNQ2–5 activation, opening the channels at more negative membrane potentials than normal and thus greatly increasing current at the subthreshold potentials, raising the barrier for neuronal firing and providing antiepileptic effects (29, 30)."
34516289
reach
"Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels."
23933653
reach
"It is well known that retigabine prevents seizures by opening Kv7.2 and Kv7.3; however, whether SUMOylation is involved in this process is unknown."
34509475