IndraLab

Statements

Ezogabine inhibits KCNQ2. 4 / 4
1 | 3
reach
"Discovery of a retigabine derivative that inhibits KCNQ2 potassium channels."
23933653
reach
"Orofacial neuropathic pain induced by oxaliplatin: downregulation of KCNQ2 channels in V2 trigeminal ganglion neurons and treatment by the KCNQ2 channel potentiator retigabine."
28741430
dgi
No evidence text available
reach
"When interacting with W265 by hydrogen bonding, utilizing its carbonyl oxygen as an H-bond acceptor (27), retigabine is able to negative-shift the voltage dependence of KCNQ2–5 activation, opening the channels at more negative membrane potentials than normal and thus greatly increasing current at the subthreshold potentials, raising the barrier for neuronal firing and providing antiepileptic effects (29, 30)."
34516289