IndraLab

Statements

SCN1A decreases the amount of GADD45GIP1. 4 / 4
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"In the current report and our previous study, we have demonstrated that NAC-1 proteins negatively regulate the expression of Gadd45gip1 (Crif1) and Gadd45gamma."
19305429
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"NAC-1 knockdown in both SKOV3 and HeLa cells that expressed abundant endogenous NAC-1 induced Gadd45GIP1 expression transcriptionally; on the other hand, engineered expression of NAC-1 in NAC-1-negative RK3E and HEK293 cells suppressed endogenous Gadd45GIP1 expression."
17804717
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"For example, NAC-1, a BTB/POZ protein, repressed transcription of the CKbetaBP2 and CRIF1 gene."
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"In summary, NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells."
17804717