IndraLab

Statements


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"However, OTUB1 only inhibited the degradation of active Smad2/3 and did not affect the inactive non-phosphorylated form or total Smad2/3 protein."

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"Therefore, the association of OTUB1 with phospho-SMAD2/3 would be predicted to prevent SMAD2/3 from being polyubiquitylated and degraded, thereby enhancing TGFbeta signalling."