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Ethanol inhibits KCNK2. 2 / 2

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"Alcohol inhibits TREK-1 in a PLD2 dependent manner [XREF_BIBR], but whether the metabolite can directly antagonize the channel has not been tested."

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"Using the cutoff determined with PLD2 as a prediction for TREK-1 inhibition and using whole cell patch clamp as a measurement, we found that octanol (8 carbons) and ethanol robustly inhibit TREK-1 currents in HEK293 cells expressing TREK-1 channels (XREF_FIG and XREF_SUPPLEMENTARY)."

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Ethanol inhibits KCNK2. 2 / 2

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