IndraLab

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USP4 increases the amount of HMGA2. 4 / 4
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"Furthermore, we point out, for the first time, that KLF2 modulates cell growth, apoptosis, and sensitivity to BTZ through HMGA2.Our study further elucidates the intricate regulatory network in BTZ-resistant MM cells by revealing that USP4 modulates HMGA2 expression via KLF2, establishing a previously uncharacterized USP4/KLF2/HMGA2 cascade in MM resistance to BTZ."
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"Future work will be warranted to uncover the downstream effectors underlying the activity of HMGA2.In summary, our study demonstrates a novel regulatory network where USP4 stabilizes KLF2 protein via deubiquitination and thus enhances HMGA2 expression, with the ability to modulate BTZ sensitivity, growth, and apoptosis of BTZ-resistant MM cells (Fig. 7C)."
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"Additionally, USP4 modulated HMGA2 expression via KLF2 in the two BTZ-resistant cell lines."
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"USP4 modulates HMGA2 expression via KLF2."
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