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BMI1 activates USP22. 3 / 3
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"These results showed that BMI1 mediates the effect of USP22 on glioma stemness."

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"Therefore, Bmi-1 and Cyclin D2 are important oncogenes in cancer and may mediate the promoting role of USP22 in human colon cancer.In conclusion, the present study systematically examined the oncogenic role of USP22 in human colon cancer."

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"Considering BMI1 is a potential target of USP22 in other cancers,21, 22 we attempted to examine whether BMI1 may mediate the effect of USP22 on glioma stemness."