IndraLab

Statements

USP22 activates cellular survival. 3 / 3
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"Moreover , USP22 depletion decreased cellular survival in response to cisplatin at 2.5 muM ( 1.9-fold ; p =0 .004 ) and 5 muM ( 3.5-fold ; p =0 .0002 ) in CRPC cells ( Figure 2E , right ) as well as HT-sensitive cells ( p =0 .001 ; Supplemental Figure 2E , right ) , indicating that USP22 is required for cellular survival after DNA damage ."
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"Accordingly , USP22 promotes cellular survival after double strand break-inducing irradiation ( Figure 2 ; Supplemental Figure 2 ; Figure 3 ) ."
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"The USP22-sensitive ubiquitylome reveals altered modification of DNA repair-related proteins The USP22-sensitive transcriptome implicated USP22 in affecting DDR-related pathways ( Figure 2 ) , and in vitro and in vivo studies demonstrated that USP22 modulates proliferative phenotypes as well as cellular survival ( Figures 2-3 ) ."
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