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USP22 deubiquitinates NFATC2. 7 / 8
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"In this study, we found that an ubiquitin-specific protease, USP22, interacts with and deubiquitinates NFATc2."
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"Consistent with previous results, overexpression of USP22 but not the USP22C185A mutant could reduce ubiquitination of NFATc2."
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"USP22 can promote the expression of interleukin-2 in T cells by deubiquitinating and stabilizing NFATc2 (an important regulator of T-cell activation)—a novel role for USP22 as a positive regulator of NFATc2 in the control of T-cell immune responses (25)."
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"NFATc2 is a regulatory molecule in T-cell activation, and USP22 promotes interleukin-2 expression in T cells by deubiquitinating and maintaining the stability of NFATc2."
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"Gao et al found that USP22 interacts with and deubiquitinates NFATc2, and also stabilizes NFATc2 protein and promotes NFATc2 function to facilitate IL-2 expression in T cells."
28791349
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"USP22 can deubiquitinate and stabilize NFATC2 to activate T cells and upregulate IL-2 release."
37658402
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"Thus, our data indicated that USP22 deubiquitinates NFATc2, which requires its enzymatic activity.Since we found that USP22 deubiquitinates NFATc2, we reasoned that USP22 might control NFATc2 stabilit[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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