IndraLab

Statements

USP7 inhibits washc1. 2 / 2
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reach
"This lead us to hypothesize that in addition to preventing TRIM27 auto-ubiquitination and degradation, USP7 also prevents over-activation of WASH and improper CI-M6PR recycling by precisely tuning WASH ubiquitination and endosomal actin levels."
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reach
"USP7 interacts with the MAGE-L2-TRIM27 complex to: first, reduce WASH activity by direct deubiquitylation of the K220 lysine and second, promote WASH activity by preventing the ubiquitylation of TRIM2[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
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