IndraLab

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FOS increases the amount of UCHL3. 5 / 5
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"Using ChIP-qPCR, we confirmed that this increased UCH-L3 gene expression is caused by direct binding of c-Fos to the UCH-L3 promoter (Fig. 3D)."
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"In GCSCs, c-Fos translocated into the nucleus and induced UCH-L3 expression under stress conditions, resulting in the inhibition of β-catenin degradation."
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"In conclusion, we demonstrated that the expression of UCH-L3 in GCSCs under stress conditions is induced by c-Fos, resulting in nuclear accumulation of β-catenin, and conferring high resistance to external stimuli by expressing stemness genes."
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"UCH-L3 expression was induced by the transcription factor c-Fos, and the levels of c-Fos increased in response to autophagy activation."
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"UCH-L3 expression in GCSCs is induced directly by c-Fos."
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