IndraLab

Statements

USP50 activates FEN1. 4 / 4
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"USP50 supports WRN:FEN1 at stalled replication forks, suppresses MUS81-dependent fork collapse and restricts double-strand DNA breaks at GC-rich sequences."
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"USP50 supports FEN1 localisation at stalled forks."
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"Further, since cells lacking FEN1 also show DNA2 and RECQL4/5-dependent suppression of replication restart, we suggest a model where USP50’s support of FEN1 restricts DNA2 and RECQL4/5 usage (Fig. 6A)."
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"Thus, USP50 promotes FEN1 presence at stalled forks."
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