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USP13 binds STING1. 28 / 28
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"Co-IP results further corroborated the exogenous interaction of USP13 and STING in NIH/3T3 cells co-transfected with Flag–USP13 and His–STING ( xref D)."
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"In contrast, the truncate (aa301-863) that preserves DUB activity and UBA motifs inhibited cGAS and STING-mediated activation of IFN-β promoter and catalysed deubiquitination of STING ( xref ), indicating that USP13-mediated deubiquitination of STING is associated with its suppression of antiviral signalling."
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"Interestingly, a previous study found that USP13 interacts with STING and promotes the deubiquitination of STING, thereby lessening the antiviral responses by decreasing the activation of STING–TBK1 signaling xref ."
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"Here, we showed the interaction between STING and USP13 in cardiomyocytes during DIC, and the K63-linked deubiquitination of STING by USP13 resulted in the STING degradation via a P62-dependent autophagic way."
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"USP13, a deubiquitinating enzyme, interacts with STING and catalyzed removal of K27 O- or K33 O-linked but not K27 R-linked polyubiquitin chains from STING."
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"Moreover, USP22 significantly promoted the interaction between USP13 and STING ( xref )."
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"Similar to WT USP22, both USP22-C185A and USP22-UCH facilitated the interaction between STING and USP13, but USP22-ZNF failed to do so ( xref )."
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"Here, we perform an unbiased screen by coimmunoprecipitation assays in cells cotransfected with FLAG-tagged DUBs and HA-STING, and find that USP13 interacts with STING."
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"Here, we perform an unbiased screen by coimmunoprecipitation assays in cells cotransfected with FLAG tagged DUBs and HA STING, and find that USP13 interacts with STING."
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"USP13 interacts with STING."
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"USP13 interacts with STING."
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"In contrast, USP5 which shares 80% sequence similarity with USP13, neither interacted with STING in an overexpression system nor inhibited cGAS and STING induced activation of IFN-beta promoter in reporter assays (XREF_FIG), indicating a specific interaction between USP13 and STING."
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"Results from endogenous immunoprecipitation and immunoblot analysis revealed that USP13 constitutively interacted with STING without viral infection in mouse bone marrow derived dendritic cells (BMDCs) and mouse embryonic fibroblasts (MEFs) (XREF_FIG)."
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"Interestingly, SeV infection transiently disrupted USP13 STING association, whereas HSV-1 infection impaired but not totally abolished the interaction between USP13 and STING (XREF_FIG)."
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"These data together suggest that USP13 interacts with STING under physiological conditions."
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"USP13 directly binds to STING and promotes the autophagy-dependent degradation of STING."
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"Since USP13 interacts with STING, an adaptor protein critically involved in innate antiviral responses, we investigated the role of USP13 in virus triggered signalling in THP-1 cells by shRNA mediated knockdown of USP13 (XREF_FIG)."
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"In contrast, USP5 which shares 80% sequence similarity with USP13, neither interacted with STING in an overexpression system nor inhibited cGAS and STING-induced activation of IFN-β promoter in reporter assays ( xref ), indicating a specific interaction between USP13 and STING."
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"Results from endogenous immunoprecipitation and immunoblot analysis revealed that USP13 constitutively interacted with STING without viral infection in mouse bone marrow-derived dendritic cells (BMDCs) and mouse embryonic fibroblasts (MEFs) ( xref )."
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"Interestingly, SeV infection transiently disrupted USP13-STING association, whereas HSV-1 infection impaired but not totally abolished the interaction between USP13 and STING ( xref )."
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"These data together suggest that USP13 interacts with STING under physiological conditions."
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"As shown in xref C, USP13–C343A still binds with STING, same as its wild-type homolog (USP13–WT)."
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"Similar to our results, a previous study revealed that the complete N-terminal (aa1–624) or C-terminal (aa625–863) region of USP13 is necessary for the interaction between USP13 and STING [37]."
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"We first confirmed the endogenous interaction between USP13 and STING proteins in HL-1 cells and cardiac tissues ( xref B and C)."
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"Since USP13 interacts with STING, an adaptor protein critically involved in innate antiviral responses, we investigated the role of USP13 in virus-triggered signalling in THP-1 cells by shRNA-mediated knockdown of USP13 ( xref )."
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"Similar to our results, a previous study revealed that the complete N-terminal (aa1–624) or C-terminal (aa625–863) region of USP13 is necessary for the interaction between USP13 and STING [ xref ]."
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"To verify the USP13–STING axis in Dox-induced cardiomyocyte death and inflammation, we constructed STING knockout (STINGKO) HL-1 cells and overexpressed USP13 in these cells."
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