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OTUB2 leads to the deubiquitination of PKM2. 3 / 3
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"For example, OTUB2 negatively regulates PKM2 ubiquitination and the depletion of OTUB2 reduces the glucose consumption, lactate production and cellular ATP production, exhibiting attenuated proliferation and migration and increased sensitivity to chemotherapy drugs for CRC [18]."
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"Yu et al. showed that OTUB2, a deubiquitinating enzyme, inhibited the ubiquitination of PKM2 by competitively binding to it with Parkin (ubiquitin E3 ligase), which enhanced the activity of PKM2 and promoted glycolysis, promoting the development of colon cancer [26]."
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"For example, OTUB2 inhibits PKM2 ubiquitination and enhances its activity in colorectal cancer [42]."
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