IndraLab

Statements

Fenofibrate inhibits RELA. 12 / 12
2 | 10
ctd
No evidence text available
25545733
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"Also, fenofibrate treatment decreased NF-kappaB p65 and cyclooxygenase 2 proteins in aortas."
30296701
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"Also, fenofibrate treatment decreased NF-kappaB p65 and cyclooxygenase 2 proteins in aortas."
30296701
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"XREF_TABLE and XREF_FIG showed that fenofibrate could significantly inhibit the up-regulation of NF-kappaB p50 and p65 proteins of EAM rats (p < 0.05)."
27095924
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"Furthermore, they proved that fenofibrate inhibited the transcriptional activity of NF-kappaB and RelA and disrupted the association of RelA and HIF1alpha, leading to the decreased PKM2 expression and mitochondrial impairment XREF_BIBR."
29760790
ctd
No evidence text available
20520642
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"Fenofibrate downregulated p-IKKa/b, p-IkappaBa, and nuclear NFkappaB (p65 and p50), which are involved in the NF-kappaB pathway, and upregulated AMPK related proteins, such as LKB1, p-AMPKalpha, p-AMPKbeta1, and AMPKgamma1."
29760790
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"We demonstrated that fenofibrate markedly inhibited the activation of the NF-kappaB p65 pathway in the lungs and intestines of mice during intestinal I/R injury, while the Ikappa Balpha activity was up-regulated compared to the vehicle group, unveiling that the anti-inflammatory property of fenofibrate in the intestinal I/R injury is through an NF-kappaB p65 dependent pathway."
26902261
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"Although other downstream target genes of fenofibrate may also take part in modulating apoptosis, the present data demonstrated that fenofibrate could potentiate chemosensitivity to human breast cancer by suppressing the activation of AKT and NF-kappaB p65 signaling pathway at least partially, which served a prominent function as an activator in apoptosis by downregulating Mcl-1 and Bcl-xl and upregulating Bok and Bax."
30774365
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"We demonstrated that fenofibrate markedly inhibited the activation of the NF-κ B p65 pathway in the lungs and intestines of mice during intestinal I/R injury, while the Iκ Bα activity was up-regulated compared to the vehicle group, unveiling that the anti-inflammatory property of fenofibrate in the intestinal I/R injury is through an NF-κ B p65 dependent pathway."
26902261
reach
"Fenofibrate prevented nuclear translocation of nuclear factor of activated T-cells c4 (NFATc4) and p65 subunit of nuclear factor-kappa B (p65-NFkappaB) induced by pressure overload or angiotensinII (AngII)."
23518069
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"Compared with the vehicle-treated DM, fenofibrate administration decreased COX-2 and NF-κB p65 proteins in the aorta (Fig. 7A and B, p < 0.01)."
30296701