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Fenofibrate inhibits RELA. 10 / 12
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"In-silico study was carried out to predict and analyze the interaction and binding affinity of compounds at the catalytic ligand binding domain of NF–κB p65 protein, to obtain a better conception of N[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31541628
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"Furthermore, they proved that fenofibrate inhibited the transcriptional activity of NF-kappaB and RelA and disrupted the association of RelA and HIF1alpha, leading to the decreased PKM2 expression and mitochondrial impairment XREF_BIBR."
29760790
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"Also, fenofibrate treatment decreased NF-kappaB p65 and cyclooxygenase 2 proteins in aortas."
30296701
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"Compared with the vehicle-treated DM, fenofibrate administration decreased COX-2 and NF-κB p65 proteins in the aorta (Fig. 7A and B, p < 0.01)."
30296701
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"We demonstrated that fenofibrate markedly inhibited the activation of the NF-kappaB p65 pathway in the lungs and intestines of mice during intestinal I/R injury, while the Ikappa Balpha activity was up-regulated compared to the vehicle group, unveiling that the anti-inflammatory property of fenofibrate in the intestinal I/R injury is through an NF-kappaB p65 dependent pathway."
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"Although other downstream target genes of fenofibrate may also take part in modulating apoptosis, the present data demonstrated that fenofibrate could potentiate chemosensitivity to human breast cancer by suppressing the activation of AKT and NF-kappaB p65 signaling pathway at least partially, which served a prominent function as an activator in apoptosis by downregulating Mcl-1 and Bcl-xl and upregulating Bok and Bax."
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"Fenofibrate downregulated p-IKKa/b, p-IkappaBa, and nuclear NFkappaB (p65 and p50), which are involved in the NF-kappaB pathway, and upregulated AMPK related proteins, such as LKB1, p-AMPKalpha, p-AMPKbeta1, and AMPKgamma1."
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"Furthermore, fenofibrate reduced the production of acetylated-NF-κB p65 (Ac-NF-κB p65) in endothelial cells activated with TNF-α, an effect that was eliminated by SIRT1 silencing."
39575188
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"In-silico study was carried out to predict and analyze the interaction and binding affinity of compounds at the catalytic ligand binding domain of NF–κB p65 protein, to obtain a better conception of N[MISSING/INVALID CREDENTIALS: limited to 200 char for Elsevier]"
31541628
reach
"XREF_TABLE and XREF_FIG showed that fenofibrate could significantly inhibit the up-regulation of NF-kappaB p50 and p65 proteins of EAM rats (p < 0.05)."
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