IndraLab

Statements


COPS6 leads to the deubiquitination of CDK9. 2 / 2
| 2

reach
"In addition, to investigate whether CSN6 controls the ubiquitination and degradation of the E3 ligase UBR5 to stabilize CDK9, in vivo ubiquitination assays were performed and found that CSN6 increased UBR5 ubiquitination levels and decreased CDK9 ubiquitination levels in melanoma cells and 293FT cells."

reach
"CSN6 promotes melanoma proliferation and metastasis by controlling the UBR5 mediated ubiquitination and degradation of CDK9."